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KMID : 0617219980090010051
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Duksung Bulletin Phamaceutical Sciences
1998 Volume.9 No. 1 p.51 ~ p.69
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Protective Effect of Salicornia Herbacea L. against Carbon Tetrachloride-Induced Hepatotoxicity in Rats
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Abstract
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The objective of this study is to investigate the effects of Salicormia Herbacea L. especially on carbon tetrachloride induced hepatotoxicity.
The Sprague Dawley Rates were administered the Salicornia Herbacea L. orally at 500 and 750㎎/㎏ for consecutive days, followed by an intraperitoneal administration of carbon tetrachloride at 0.4㎖/㎏ in corn oil.
The elevated alanine aminotransferase(ALT) and aspartate aminotransferase (AST) activities, which had been induced by the administration of Salicornia Herbacea L.
The liver vacuolization and lymphoid cell aggregation by carbon tetrachloride were clearly elevated by the Salicornia Herbacea L. as determined by histological examinations. All data from this study showed that the administration of Salicornia Herbacea L. prior to CCl_4 injection, resulted in the protection of rats from hepatotoxicity, suggesting that it could be used to develop new drug with protective effect against hepatotoxicity.
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